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  • 11.03.2010
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Brca1 mutation breast cancer

contralateral breast cancer for BRCA1 and BRCA2 mutation. A small percentage of people (about one in , or % of the population) carry mutated BRCA1 or BRCA2 genes. A BRCA mutation occurs when the DNA . Women who inherit a deleterious BRCA1 or BRCA2 mutation face substantially increased risks of developing breast cancer, which is estimated. The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers. The cumulative risk estimates for developing breast cancer by age 80 were 72% for BRCA1 carriers and 69% for BRCA2 carriers. Women who inherit a mutation in certain genes such as BRCA1, BRCA2, and PALB2 from their mother or father have a much higher-than-average risk of developing breast cancer and/or ovarian cancer. Learn about testing for inherited gene abnormalities. Sep 04,  · BRCA1- and BRCA2-associated hereditary breast and ovarian cancer syndrome (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (includes fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a BRCA2 pathogenic Cited by:
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